Peptides
FOXO4-DRI 10mg
FOXO4-DRI is a retro-inverso D-amino-acid peptide designed to disrupt the FOXO4-p53 interaction in senescent cells. It is a widely used tool compound in senolytic research.
Sign in to see pricing and order
Listings and prices are shown to registered researchers only. Registration is free and takes about thirty seconds.
- Same-day dispatch before 2 PM PT from British Columbia, Canada
- Free shipping over CA$200
- Batch-specific COA with every lot
- Priced in Canadian dollars
Specification
- Catalogue number
- OP-059
- Purity specification
- >99%
- Fill
- 10mg
- CAS number
- 2460055-10-9
- Molecular weight
- 5358.06 g/mol
- Form
- Lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Shelf Life
- 24 months from date of manufacture
About FOXO4-DRI 10mg
Senescent cells resist apoptosis in part by sequestering p53 in the nucleus through FOXO4 binding. FOXO4-DRI competes for that interaction, releasing p53 to trigger apoptosis selectively in cells where the mechanism is active. The retro-inverso design, a reversed sequence built from D-amino acids, is what gives the peptide protease resistance while preserving the side-chain topology needed for binding. The original 2017 Cell paper by Baar and colleagues is the reference work. It is one of the more expensive research peptides because D-amino-acid synthesis at this length is demanding.
Storage and reconstitution
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
Shipping within Canada
Orders placed before 2:00 PM Pacific on a business day are packed and dispatched the same day. Orders placed after that cut-off, or on a weekend or statutory holiday, are dispatched on the next business day. Parcels leave British Columbia, Canada and travel entirely within the country, so nothing on this order crosses a border, clears customs or is held by CBSA. Orders over CA$200 ship free; see the shipping page for transit times by province.
Related compounds
All Peptides →- Featured
- Featured
