Peptides
ACE-031 1mg
ACE-031 is a soluble decoy receptor built by fusing the extracellular domain of activin receptor type IIB to an IgG1 Fc region. It sequesters myostatin and related TGF-beta ligands before they reach the membrane receptor.
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- Same-day dispatch before 2 PM PT from British Columbia, Canada
- Free shipping over CA$200
- Batch-specific COA with every lot
- Priced in Canadian dollars
Specification
- Catalogue number
- OP-049
- Purity specification
- >99%
- Fill
- 1mg
- Molecular weight
- ~90,000 g/mol (Fc-fusion protein)
- Form
- Lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Shelf Life
- 24 months from date of manufacture
About ACE-031 1mg
Rather than blocking myostatin at the receptor, ACE-031 removes it from circulation: the ActRIIB extracellular domain binds myostatin, activin A and GDF-11 with high affinity, and the Fc fusion gives the construct a long half-life. That broad ligand promiscuity is both its strength as a research tool and the reason its clinical development in Duchenne muscular dystrophy was halted, since off-target ligand sequestration produced vascular effects. It is a large recombinant fusion protein, not a peptide, and requires strict cold-chain handling and gentle reconstitution to avoid denaturation.
Storage and reconstitution
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
Shipping within Canada
Orders placed before 2:00 PM Pacific on a business day are packed and dispatched the same day. Orders placed after that cut-off, or on a weekend or statutory holiday, are dispatched on the next business day. Parcels leave British Columbia, Canada and travel entirely within the country, so nothing on this order crosses a border, clears customs or is held by CBSA. Orders over CA$200 ship free; see the shipping page for transit times by province.
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