Peptides
PE 22-28 10mg — Research Peptide Canada
PE 22-28 is a seven-amino-acid fragment of spadin, itself derived from the propeptide of sortilin. It is studied as a blocker of the TREK-1 potassium channel, a target implicated in antidepressant response.
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- Same-day dispatch before 2 PM PT from British Columbia, Canada
- Free shipping over CA$200
- Batch-specific COA with every lot
- Priced in Canadian dollars
PE 22-28 10mg specification
Release specification
- Catalogue number
- OP-066
- Purity specification
- >99%
- Fill
- 10mg
Identity and structure
- CAS number
- 1801959-12-5
- Molecular weight
- 773.89 g/mol
Additional specifications
- Form
- Lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Shelf Life
- 24 months from date of manufacture
About PE 22-28 10mg
TREK-1 knockout animals show a depression-resistant phenotype, which made the channel an attractive target and led to the identification of spadin as an endogenous blocker. PE 22-28 is the minimal active fragment of that peptide, retaining channel-blocking activity at a fraction of the length. What makes it interesting mechanistically is the reported speed of onset in animal models, on the order of days rather than the weeks associated with monoaminergic antidepressants, which points to a distinct pathway. Independent replication outside the originating groups remains limited.
Storing and handling PE 22-28 10mg
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
Shipping PE 22-28 10mg within Canada
Orders placed before 2:00 PM Pacific on a business day are packed and dispatched the same day. Orders placed after that cut-off, or on a weekend or statutory holiday, are dispatched on the next business day. Parcels leave British Columbia, Canada and travel entirely within the country, arriving in two to five business days with a tracking number on every one. Orders over CA$200 ship free; see the shipping page for the dispatch cut-off and transit window.
PE 22-28 10mg questions
Are research peptides like PE 22-28 10mg legal in Canada?
PE 22-28 10mg is supplied here strictly as a reference material for in vitro laboratory research. For laboratory research use only. Not for human or veterinary use. Canadian law turns on what a substance is represented and supplied for, which is why that restriction is on the label, the invoice and every page of this site. The full framework, and what a research-use designation does and does not change, is set out on our legality page.
Is PE 22-28 10mg shipped from within Canada?
Yes. Every PE 22-28 10mg order leaves British Columbia, Canada and travels entirely within the country. Orders placed before 2:00 PM Pacific on a business day are packed and dispatched the same day. Orders placed after that cut-off, or on a weekend or statutory holiday, are dispatched on the next business day. Transit after dispatch is 2–5 business days Canada-wide, with a tracking number on every parcel, and orders over CA$200 ship free.
Does PE 22-28 10mg come with a certificate of analysis?
Yes — the certificate for the lot in your box, not a representative certificate for a different batch. Every PE 22-28 10mg lot is released against a >99% HPLC specification, and the document carries the lot number, the issuing laboratory and the analytical method. Certificates are not published on this site; if you need another copy, ask us for it by lot number.
How is PE 22-28 10mg supplied and stored?
As a lyophilised powder in a sealed vial, which is the form that survives shipping without a cold chain. Unopened vials are stored away from light and moisture; the storage and handling page covers the laboratory conditions in full. We publish no dosing, reconstitution volumes or administration guidance of any kind.
What fill is PE 22-28 10mg supplied in?
PE 22-28 10mg is supplied in a single 10mg fill, released against a >99% specification.
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